vbid/9780323991780

Description

Cancer glycobiology is a blazing hot area of cancer research with aberrant post-translational glycosylations on lipids and proteins considered critical for cancer development and metastasis.� The NIH/NCI Alliance of Glycobiologists for Cancer Research is a consortium of (10) tumor glycobiology laboratories funded to investigate how cancer-associated glycans (CAG) impact the development and metastasis of cancer.� The hope of this momentous effort is to discover CAGs for use as novel biomarkers to detect early-stage cancer or its aggressive behavior or, alternatively, as novel molecular targets with the promise of a curative approach to cancer therapy.� The mission of the �Alliance� is to study structure and function of CAGs in cancer development and to provide clinically useful biomarkers for detecting cancer early or the potential of metastasis.� This charge has stimulated extensive collaborations across US and International institutions to accelerate discovery of glycan-based biomarkers to the forefront of NCI’s efforts to diagnose early-stage cancer and provide curative anti-cancer therapies.�

The main goals of these research efforts are: 1.� To identify and study how cancer-associated glycans functionally impact cancer growth and metastasis 2.� To identify cancer-associated glycans that can serve as biomarkers for the detection or progression of cancer 3.� To develop cancer-associated glycans as novel therapeutic targets for the treatment and cure of cancer

This volume consists of (9) chapters, one from each funded laboratory, that reviews new methods and mechanisms� highlighting glycoconjugates and their roles as cancer biomarkers and/or anti-cancer therapeutic targets.

• Historical and Novel Glycobiological Biomarkers of Cancer and Disease Progression
• Novel Glycobiological Mechanisms Driving Cancer Progression
• Novel Methods for Discovering Glycobiological Biomarkers of Cancer

Typham this is the title: Novel Methods and Pathways in Cancer Glycobiology Research 1st Edition