Description

Specifically geared to personnel in the pharmaceutical and biotechnology industries, this book describes the basics and challenges of oral bioavailability – one of the most significant hurdles in drug discovery and development.

•�� Describes approaches to assess pharmacokinetics and how drug efflux and uptake transporters impact oral bioavailability
•�� Helps readers reduce the failure rate of drug candidates when transitioning from the bench to the clinic during development
•�� Explains how preclinical animal models – used in preclinical testing – and in vitro tools translate to humans, which is an underappreciated and complicated area of drug development
•�� Includes chapters about pharmacokinetic� modelling, the Biopharmaceutics Drug Disposition Classification System (BDDCS), and the Extended Clearance Classification System (ECCS)
•�� Has tutorials for applying strategies to medicinal chemistry practices of drug discovery/developmentTypham this is the title: Oral Bioavailability Assessment: Basics and Strategies for Drug Discovery and Development 1st Edition