vbid/9781461458944

Description

???????Prominin-1 or otherwise known as CD133 is a glycoprotein that is�present in humans and mice.�Since the first description of prominin in 1997, in mouse neuroepithelial cells and in human hematopoietic stem cells as AC133 antigen, this molecule has aroused a large interest especially, as a stem cell marker, that gave rise to an ever growing body of publications and more recently its expression in cancer stem cells. Controversies as to its role as a cancer stem and its detection in different models, as well as its use as a prognostic marker have emerged. Yet, beyond its use as a stem cell and cancer stem cell marker, prominin-1/CD133 displays unique biological features and appears of importance in other processes like for example in retinal biogenesis. Indeed, this five-transmembrane plasma membrane glycoprotein, which�marks membrane protrusions is associated with several essential processes like cell polarity, asymmetric cell division and membrane remodeling. We propose to review current knowledge about this intriguing molecule and present�pertinent information to determine the biological role of prominins and assess their importance in medicine and cancer research.�The primary audience for this book is geared towards scientists and researchers with interest�in cancer stem cells, stem cells,�cell biology, neurobiology, and regenerative medicine.Typham this is the title: Prominin-1 (CD133): New Insights on Stem & Cancer Stem Cell Biology