vbid/9781489980533

Description

This addition to the Springer Brief in Stem Cells series�focuses on aspects related to the specific mechanisms that ensure and control pluripotency and cell commitment in domestic animal species. This topic is generating�rapidly-increasing interest due to the great potential for domestic animal species to be used as�intermediate biomedical models,�between the mouse and the human.�The Brief�addresses why we�need large animal models for regenerative medicine. It also describes early embryo development with a careful and specific analysis of the regulatory mechanisms driving cleavage, polarization and genome activation in domestic species. How pluripotency is�compartmentalized in domestic species as well as the different aspects that make the derivation of stem cells in domestic species very difficult are also addressed.Typham this is the title: Pluripotency in Domestic Animal Cells