vbid/9783034806824

Description

Gamma-Glutamyl Transpeptidases (?-GTs) are members of the N-terminal nucleophile hydrolase superfamily, enzymes that cleave the ?-glutamyl amide bond of glutathione to liberate cysteinylglycine. The released ?-glutamyl group can be transferred to water (hydrolysis) or to amino acids or short peptides (transpeptidation). ?-GT plays a key role in the gamma glutamyl cycle by regulating the cellular levels of the antioxidant glutathione, hence it is a critical enzyme in maintaining cellular redox homeostasis.?-GT is upregulated during inflammation and in several human tumors, and it is involved in many physiological disorders related to oxidative stress, such as Parkinson�s disease and diabetes. Furthermore, this enzyme is used as a marker of liver disease and cancer. This book covers�current knowledge about the structure-function relationship of ?-GTs and�gives information about�applications of ?-GTs in different fields ranging from clinical biochemistry to biotechnology and biomedicine.?Typham this is the title: Gamma-Glutamyl Transpeptidases Structure and Function