vbid/9783319701783

Description

The book provides a�reference for years to come, written by world-renowned expert investigators studying sex differences, the�role of sex hormones, the systems biology of sex, and the genetic contribution of sex chromosomes to�metabolic homeostasis and diseases. In this volume, leaders of the pharmaceutical industry present their views on�sex-specific drug discovery. Many of the authors presented at the Keystone Symposium on �Sex and gender factors affecting metabolic homeostasis, diabetes and obesity� to be held in�March 2017 in Lake Tahoe, CA. This book will generate new�knowledge and ideas on the importance of gender biology and medicine from a molecular standpoint to�the population level and to provide the methods to study them. It is intended to be a�catalyst leading to gender-specific treatments of metabolic diseases. There are fundamental aspects of metabolic homeostasis that are regulated differently in males and�females, and influence both the development of diabetes and obesity and the response to�pharmacological intervention. Still, most preclinical researchers avoid studying female rodents due to the�added complexity of research plans. The consequence is a generation of data that risks being relevant�to only half of the population. This is a timely moment to publish a book on sex differences in diseases as�NIH leadership has asked scientists to consider sex as a biological variable in preclinical research, to ensure�that women get the same benefit of medical research as men.Typham this is the title: Sex and Gender Factors Affecting Metabolic Homeostasis, Diabetes and Obesity