vbid/9783319906959

Description

This book looks at where stem cell technology is presently and how it is instrumental�in advancing the field of disease modeling and cell transplantation. By focusing on�major human disorders such as Alzheimer�s disease, cancer, and heart disorders, the�book summarizes the major findings in the field of human stem cells and dissect�the current limitations on our understanding of stem cells biology. The chapters�focus on the genetics, genomics, epigenetics and physiology of stem cells models,�together with technological advances on molecular biology such as CRISPR/Cas9 or�epigenetic editing, that will be instrumental in the future of human disease modeling�and treatment.� In base of the limitations of current disease models and in front of the unmet necessity�of finding therapeutical interventions for human disorders, the availability of stem�cell technology has opened new doors for several fields. The unlimited self-renewal�capacity and more extensive differentiation potential of stem cells offers a theoretically�inexhaustible and replenishable source of any cell subtype. Since Professor Shinya�Yamanaka described it, 10 years ago in his seminal paper, that somatic cells could be�reprogrammed to inducible stem cells (iPSC) just by expressing four transcription�factors, the field of has exploded, especially its applications in biomedical research.Typham this is the title: Stem Cell Genetics for Biomedical Research Past, Present, and Future